Journal article
Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia
JC Cutts, K O’Flaherty, SG Zaloumis, EA Ashley, JA Chan, MA Onyamboko, C Fanello, AM Dondorp, NP Day, AP Phyo, M Dhorda, M Imwong, RM Fairhurst, P Lim, C Amaratunga, S Pukrittayakamee, TT Hien, Y Htut, M Mayxay, M Abdul Faiz Show all
Journal of Infectious Diseases | Published : 2022
Abstract
Background. Understanding the effect of immunity on Plasmodium falciparum clearance is essential for interpreting therapeutic efficacy studies designed to monitor emergence of artemisinin drug resistance. In low-transmission areas of Southeast Asia, where resistance has emerged, P. falciparum antibodies confound parasite clearance measures. However, variation in naturally acquired antibodies across Asian and sub-Saharan African epidemiological contexts and their impact on parasite clearance re yet to be quantified. Methods. In an artemisinin therapeutic efficacy study, antibodies to 12 pre-erythrocytic and erythrocytic P. falciparum antigens were measured in 118 children with uncomplicated P..
View full abstractRelated Projects (3)
Grants
Awarded by Ian Potter Foundation
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (project grant 1060785 to F. N., J. A. S., and F. J. I. F., program grant 637406 to J. G. B., and career development fellowship 1166753 to F.J.I.F., and leadership investigator grants 1077636 to J. G. B. and 1196068 to J.A.S.); the Australian Research Council (Future Fellowships FT130101122 to F. J. I. F. and FT0992317 to J. G. B.); the Ramaciotti Foundation (establishment grant 3245/2011 to F. J. I. F.); the Ian Potter Foundation (grant to F. J. I. F.); the Australian Centre for Research Excellence on Malaria Elimination, funded by the NHMRC of Australia (grant 1134989); the Victorian Operational Infrastructure Support Program (support to the Burnet Institute); the UK Department for International Development; the Worldwide Antimalarial Resistance Network; the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health; and the Wellcome Trust (grant 220211). Funding to pay the Open Access publication charges for this article was provided by the Burnet Institute.